Normal Mode Analysis of KRas4B Reveals Partner Specific Dynamics
نویسندگان
چکیده
منابع مشابه
Functional dynamics of PDZ binding domains: a normal-mode analysis.
Postsynaptic density-95/disks large/zonula occludens-1 (PDZ) domains are relatively small (80-120 residues) protein binding modules central in the organization of receptor clusters and in the association of cellular proteins. Their main function is to bind C-terminals of selected proteins that are recognized through specific amino acids in their carboxyl end. Binding is associated with a deform...
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Few would disagree, but a generation later, the statement remains a prophecy rather than fact. Although 41,000 protein structures are known, there are none for which there is a complete description of the dynamics that is often key to understanding functional mechanism. Despite keen interest in protein dynamics, studies have remained the purview of computer simulation while the challenges of ex...
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ژورنال
عنوان ژورنال: The Journal of Physical Chemistry B
سال: 2021
ISSN: 1520-6106,1520-5207
DOI: 10.1021/acs.jpcb.1c00891